Nephropathy associated with use of a Chinese herbal product containing aristolochic acid.
نویسندگان
چکیده
The selection of medical students is an important issue for the community and the medical profession because of the high costs involved in medical education and the need for graduates to be good doctors. Since the 1970s, the method of selecting medical students in Australia has evolved from the use of purely academic criteria based on secondary school matriculation results to the use of interviews that assess personal characteristics, and more recently to tests of aptitude — the Undergraduate Medicine and Health Sciences Admission Test (UMAT) and Graduate Australian Medical School Admissions Test (GAMSAT). The imperative for change in the selection process has been the perceived need for doctors to provide academically and clinically appropriate medical care in a professional and humane manner that is appropriate for the society in which they work. Additionally, reliance on results achieved in high school has been held to introduce considerable socioeconomic bias (BMJ 2002; 324: 952-957). While some of the steps taken to reduce socioeconomic disadvantage are transparent, such as pathways designed to improve access of Indigenous and rural students to medical school, the rationale supporting the use of interviews and aptitude tests has not been well articulated. These methods add complexity and cost to the selection process, and their evaluation is a priority. The Journal has published comment (MJA 2008; 188: 323-324) and research on the selection of medical students over many years, including papers on the role of the interview (MJA 2008; 188: 349-354), the effect of coaching (MJA 2008; 189: 270-273) and the role of the GAMSAT (MJA 2007; 186: 120-123). Unsurprisingly, there seems to be agreement that academic ability is a good predictor of completing medical school, but the minimum level of academic ability required is not certain. Studies assessing other selection methods suggest that the additional benefit conferred by the interview may be small and that of the GAMSAT may be negligible. In this issue of the Journal (page 341), Wilkinson and colleagues contribute to this debate with the first peer-reviewed data on the predictive validity of the UMAT for medical students’ academic performance. The paper shares limitations of other studies in this area — it is a correlation study (and thus cannot prove causation), it assesses outcomes in a highly performing and selected cohort of potential students (“range restriction”) who might all be expected to perform well in medical school, and it does not evaluate the clinical performance of students after graduation. Wilkinson et al’s finding that there is only weak correlation between UMAT results and performance in medical school makes it vital that research into selection processes continues. It remains to be seen whether the UMAT predicts clinical performance and contribution to the medical profession and the health of the community, but early indications seem to suggest it has little to offer.
منابع مشابه
Chinese Herbs Containing Aristolochic Acid Associated with Renal Failure and Urothelial Carcinoma: A Review from Epidemiologic Observations to Causal Inference
Herbal remedies containing aristolochic acid (AA) have been designated to be a strong carcinogen. This review summarizes major epidemiologic evidence to argue for the causal association between AA exposure and urothelial carcinoma as well as nephropathy. The exposure scenarios include the following: Belgian women taking slimming pills containing single material Guang Fang Ji, consumptions of mi...
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The term "aristolochic acid nephropathy" (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as "Chinese herbs nephropathy"), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial ma...
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Chinese herbal medicine preparations are widely available and often regarded by the public as natural and safe remedies for a variety of medical conditions. Nephropathy caused by Chinese herbs has previously been reported, usually involving the use of aristolochic acids. We report a 23-year-old woman who developed acute renal failure following prolonged use of a proprietary Chinese herbal slimm...
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متن کاملAristolochic acid, an herbal carcinogen, sold on the Web after FDA alert.
to the editor: In 2001, the Food and Drug Administration (FDA) issued warnings and an import alert that herbal products are unsafe if they contain or are suspected to contain aristolochic acid.1 A report in the Journal in 2000 described a cohort of 105 patients in whom rapidly progressive nephropathy developed after they had been given an herbal weight-loss product containing aristolochic acid ...
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ورودعنوان ژورنال:
- The Medical journal of Australia
دوره 194 7 شماره
صفحات -
تاریخ انتشار 2011